Leading the Way at Weill Cornell—daedalusfund

Projects Selected for Funding


Left to right: Dolan Sandhi (member of Dr. Ronald G. Crystal’s project team), Edouard Mullarkey (member of Lewis C. Cantley’s project team), Olivier Elemento, Haiying Zhang, and Gang Lin. Not present: Drs. Lewis C. Cantley and Ronald G. Crystal. (photo credit: Studio Brooke)

Small Molecule Inhibitors of PHGDH to Treat Cancers Addicted to Serine Synthesis
Lewis C. Cantley, PhD, Director, Sandra and Edward Meyer Cancer Center Professor of Cancer Biology in Medicine

Genetic Modification of Neurons to Express Anti-Phospho-Tau Monoclonal Antibodies to Block Pathologic Tau Accumulation in Chronic Traumatic Encephalopathy
Ronald G. Crystal, MD, The Bruce Webster Professor of Internal Medicine Professor of Medicine Professor of Genetic Medicine Chairman of Genetic Medicine

Using Big Data to Predict the Targets of Orphan Small Molecules and Accelerate Drug Discovery
Olivier Elemento, PhD, Walter B. Wriston Research Scholar, Associate Director, HRH Prince Alawaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Medicine, Head, Computational Biology Group, Caryl and Israel Englander Institute for Precision Medicine, Associate Professor of Physiology and Biophysics, and Associate Professor of Computational Genomics in Computational Biomedicine

Noncovalent Fungal Proteasome Selective Inhibitors as Anti-Fungal Agents
Gang Lin, PhD, Associate Professor of Research in Microbiology and Immunology

HIF-Stabilization and the Prevention of Hyperoxia-induced Neonatal Lung Disease
Randi B. Silver, PhD, Associate Dean, Weill Cornell Graduate School of Medical Sciences Professor of Physiology and Biophysics

Sphingolipids and Sphingolipid Synthesis Activators to Alleviate Bronchial Reactivity
Stefan Worgall, Ph.D., M.D. Distinguished Professor of Pediatric Pulmonology Professor of Pediatrics Professor of Genetic Medicine

Development of a Novel Exosome-Nanoparticle Hybrid Based Strategy for Organ Specific Drug Delivery
Haiying Zhang, PhD, Assistant Professor of Cell and Developmental Biology in Pediatrics


Left to right: Shain Rafii, Juan Cubillos-Ruiz, Theodore Schwartz, Pengbo Zhou
(photo credit: Studio Brooke)

Enhancing Cancer Immunotherapy via Targeted Silencing of ER Stress Sensors
Juan Cubillos-Ruiz, PhD, Assistant Professor of Microbiology and Immunology

Engineering Vascular Cells for Multi-Organ Repair to Mitigate Radiation and Chemical Injuries
Shahin Rafii, MD, Arthur Belfer Professor of Genetic Medicine, Professor of Genetic Medicine, and Professor of Reproductive Medicine

Femtosecond Laser Scalpel for Epilepsy Microsurgery
Theodore H. Schwartz, MD, David and Ursel Barnes Professor of Minimally Invasive Neurosurgery, Professor of Neurological Surgery, Professor of Neurological Surgery in Otolaryngology, and Professor of Neuroscience

Ubiquitin Ligase Inhibitors as Protective Agents against Cancer
Pengbo Zhou, PhD, Professor of Pathology and Laboratory Medicine


Left to right: David Lyden, Enrique Rodriguez-Boulan, Stefano Rivella
(photo credit: Studio Brooke)

Novel Non-Opioid Anti-Hyperalgesics for the Treatment of Peripheral Neuropathic Pain
Peter A. Goldstein, MD, Professor of Anesthesiology, Associate Professor of Anesthesiology in Healthcare Policy and Research, and Associate Professor of Medical Ethics in Medicine

Development of Reversible, Immunoproteasome-Selective Inhibitors for Treatment of Inflammatory Bowel Disease
Gang Lin, PhD, Associate Research Professor of Microbiology and Immunology

Development of Circulating Exosomes: Novel Biomarkers for Cancer Detection and Determining Metastatic Potential at Diagnosis and During Treatment Response
David C. Lyden, MD, PhD, Stavros S. Niarchos Professor in Pediatric Cardiology, and Professor of Pediatrics

Development of a Universal Approach to Cure Hemoglobinopathies
Stefano Rivella, PhD, Associate Professor of Genetic Medicine in Pediatrics

Development and Optimization of New Therapy for Lipofuscin-Driven Retinal Degenerative Diseases
Enrique Rodriguez-Boulan, MD, The Charles and Margaret Dyson Professor in Ophthalmology Research, Professor of Cell and Developmental Biology, and Professor of Cell Biology in Ophthalmology .