Data from a 76-year-old man with prostate cancer metastatic to bone. Coronal maximum intensity projection images are shown at (a) 1 week prior to the start of chemotherapy, (b) during week 6, and (c) after 12 weeks of therapy. (d-f) Corresponding maximum intensity projection images of the lumbar spine generated from a STIR data set at the same time points. Because of overlapping signals in the STIR data set from cerebrospinal fluid, only coronal slices intersecting the lumbar spine anterior to the vertebral foramina were included. The lesion in L2 denoted by dark arrows on the diffusion-weighted series and light arrows on the STIR series suggests a more positive response to therapy than most other lesions.